Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate

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Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.

Antibodies specifically reacting with platelets only in the presence of EDTA, by the platelet immunofluorescence test, were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination. These antibodies reacted optimally at 0-4 degree C. In 19 patients, IgG antibodies were detected; in 8 patients, IgM or IgA antibodies were also found. In o...

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Antibodies Dependent on Ethylene Diamine Tetra-Acetate

Antibodies specifically reacting with platelets only in the presence of EDTA. by the platelet immunofluorescence test. were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination. These antibodies reacted optimally at 0-4’C. In 1 9 patients. IgG antibodies were detected; in 8 patients. 1gM or IgA antibodies were also found. In one pat...

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Antibodies Dependent on Ethylene Diamine Tetra-Acetate

Antibodies specifically reacting with platelets only in the presence of EDTA. by the platelet immunofluorescence test. were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination. These antibodies reacted optimally at 0-4’C. In 1 9 patients. IgG antibodies were detected; in 8 patients. 1gM or IgA antibodies were also found. In one pat...

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EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA.

AIMS To clarify the mechanisms involved in the development of EDTA dependent pseudothrombocytopenia, particularly the platelet receptors. METHODS Platelets were measured in 33 patients with pseudothrombocytopenia, using different anticoagulants to collect blood samples (direct test). The results were compared with the counts obtained by adding patients' serum or immunoglobulins to normal bloo...

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Anticoagulant pseudothrombocytopenia with platelet satellitism.

Correspondence: Giuseppe Longo, Dipartimento di Scienze Mediche, Oncologiche e Radiologiche, Sezione di Medicina Interna, via Del Pozzo 71, 41100 Modena, Italy. Phone: international +39-059-422782 – Fax: international +39-059-424549 – E-mail: [email protected] aware that some thrombocytopenias of uncertain etiology may be artifactual in particular conditions; spurious thrombocytopenia due to EDTA-...

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ژورنال

عنوان ژورنال: Blood

سال: 1982

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v59.1.157.157